Antrodia cinnamomea and its compound dehydroeburicoic acid attenuate nonalcoholic fatty liver disease by upregulating ALDH2 activity

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Title:	Antrodia cinnamomea and its compound dehydroeburicoic acid attenuate nonalcoholic fatty liver disease by upregulating ALDH2 activity
Authors:	Cao, Yi-ni Yue, Shan-shan Wang, An-yi Xu, Lu Hu, Yi-tong Qiao, Xue Wu, Tung-Ying Ye, Min Wu, Yang-Chang Qi, Rong
Contributors:	健康暨護理學院
Keywords:	Nonalcoholic fatty liver disease Antrodia cinnamomea Dehydroeburicoic acid Aldehyde dehydrogenase 2 4-HNE
Date:	2022
Issue Date:	2023-12-28T06:53:22Z (UTC)
Abstract:	Ethnopharmacological relevance: Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disease, but currently has no specific medication in clinic. Antrodia cinnamomea (AC) is a medicinal fungus and it has been shown that AC can inhibit high fat diet (HFD)-induced lipid deposition in mouse livers, but the effective monomer in AC and mechanism against NAFLD remain unclear. It has been reported that aldehyde dehydrogenase 2 (ALDH2) activation shows protective effects on NAFLD. Our previous study demonstrates that AC and its monomer dehydroeburicoic acid (DEA) can upregulate the ALDH2 activity on alcoholic fatty liver disease mouse model, but it is not clear whether the anti-NAFLD effects of AC and DEA are mediated by ALDH2. Aim to study: To elucidate the active compound in AC against NAFLD, study whether ALDH2
Appears in Collections:	[Department of Food Science and Nutrition] Papers

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