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    Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/4206


    Title: In Vitro and In Vivo Antimicrobial Activities of Vancomycinand Rifampin against Elizabethkingia anophelis
    Authors: I-Fan, Lin 1;Lai, Chung-Hsu;Lin, Shang-Yi;Lee, Ching-Chi;Lee, Nan-Yao;Liu, Po-Yu;Yang, Chih-Hui;Huang, Yi-Han;Lin, and Jiun-Nong
    Contributors: 健康科學管理學院
    Date: 2024-03-29
    Issue Date: 2024-03-29T06:34:13Z (UTC)
    Abstract: Elizabethkingia anophelis has emerged as a critical human pathogen, and a number of
    isolated reports have described the successful treatment of Elizabethkingia infections with vancomycin,
    a drug that is typically used to target Gram-positive bacteria. This study employed in vitro broth
    microdilution checkerboard and time-kill assays, as well as in vivo zebrafish animal models to
    evaluate the individual and combination antimicrobial effects of vancomycin and rifampin against
    E. anophelis. The minimum inhibitory concentration ranges of vancomycin and rifampin against
    167 isolates of E. anophelis were 16–256 mg/L and 0.06–128 mg/L, respectively. The checkerboard
    assay results revealed a synergistic effect between vancomycin and rifampin in 16.8% (28/167) of
    the isolates. Time-kill assays were implemented for 66 isolates, and the two-drug combination had a
    synergistic interaction in 57 (86.4%) isolates. In vivo zebrafish studies revealed that treatment with
    vancomycin monotherapy, rifampin monotherapy, or vancomycin–rifampin combination therapy
    yielded a higher survival rate than the control group treatment with 0.9% saline. The results of this
    study support the use of vancomycin to treat E. anophelis infections.
    Appears in Collections:[Department of Information Technology] Research Projects

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