Meiho University Institutional Repository:Item 987654321/3156
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 2880/3801 (76%)
Visitors : 3905265      Online Users : 816
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/3156


    Title: Sinularin Induces Apoptosis through Mitochondria Dysfunction and Inactivation of the pI3K/Akt/mTOR Pathway in Gastric Carcinoma Cells
    Authors: Yu-JenWu;Bing-Sang Wong;Shu-Hao Yea;Chi-I Lu;Shun-Hsiang Weng
    Keywords: sinularin;gastric cancer;apoptosis;mitochondrial dysfunction
    Date: 2016
    Issue Date: 2016-09-21T01:48:28Z (UTC)
    Abstract: Sinularin is an active compound isolated from the cultured soft coral Sinularia flexibilis. In this study, we investigated the effects of sinularin on two human gastric cancer cell lines, AGS and NCI-N87. Our results demonstrated that sinularin suppressed the proliferation of gastric cancer cells in a dose-dependent manner and induced apoptosis. In addition, the loss of mitochondrial membrane potential, the release of cytochrome C, the activation of Bax, Bad and caspase-3/9, and the suppression of p-Bad, Bcl-xL and Bcl-2 were observed in the cells treated with sinularin. This finding suggests that sinularin-induced apoptosis is associated with mitochondria-mediated apoptosis and occurs through caspase-dependent pathways. Furthermore, sinularin inhibited the phosphoinositol 3-kinase/Akt/mechanistic target of the rapamycin signaling pathway. Taken together, our results show that sinularin-induced apoptosis is mediated by activation of the caspase cascade and mitochondrial dysfunction. Our findings suggest that sinularin merits further evaluation as a chemotherapeutic agent for human gastric cancer.
    Relation: Drugs 2016, 14, 142; doi:10.3390/md14080142
    Appears in Collections:[Department of Food Science and Nutrition] Papers

    Files in This Item:

    File Description SizeFormat
    marinedrugs-14-00142.pdffulltext4284KbAdobe PDF1490View/Open


    View Licence

    All items in MUIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback