Intra-coronary administration of cyclosporine limits infarct size, attenuates remodeling and preserves left ventricular function in porcine acute anterior infarction

Meiho University Institutional Repository > 健康暨護理學院 > 護理系 > 期刊論文 > Item 987654321/1181

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.meiho.edu.tw/ir/handle/987654321/1181

题名:	Intra-coronary administration of cyclosporine limits infarct size, attenuates remodeling and preserves left ventricular function in porcine acute anterior infarction
作者:	Sheu JJ;Chua S;Sun CK;Chang LT;Yen CH;Wu CJ;Fu M;Yip HK
关键词:	Acute myocardial infarction;Mini-pig model;Intra-coronary administration of cyclosporine
日期:	2009
上传时间:	2011-09-27T03:12:10Z (UTC)
摘要:	BACKGROUND: We tested whether intra-coronary administration of cyclosporine effectively preserves left ventricular (LV) function in porcine acute anterior wall infarction (AMI). METHODS AND RESULTS: Eighteen male mini-pigs were randomized into groups 1 (control), 2 (AMI alone), and 3 (AMI with cyclosporine treatment). AMI was induced by ligating middle left anterior descending artery (LAD). Fifteen minutes after ligation, saline and cyclosporine (2.5 mg) combination was injected into LAD beyond ligation in groups 2 and 3, respectively. Echocardiography was performed after 14 days, followed by animal sacrifice. Larger infarcted area (IA) was noted in group 2 than in group 3 (p < 0.001). In both IA and peri-IA, mRNA expressions of IL-8, MMP-9, caspase 3 and Bax were higher, whereas PGC-1α, eNOS and Bcl-2 were lower in group 2 than in groups 1 and 3 (p < 0.01). The mRNA expression of IL-10 was upregulated in both IA and peri-IA in group 3 compared with groups 1 and 2. Apoptotic nuclei and CD40-positive cells were higher in both peri-IA and non-IA in group 2 than in groups 1 and 3 (p < 0.001). Oxidative stress and cytosolic cytochrome C in IA were increased in group 2 than in groups 1 and 3 (p < 0.001). Mid-LV end-systolic areas were higher, whereas mid-LV wall fractional area change was lower in group 2 than in groups 1 and 3 (p < 0.001). CONCLUSIONS: Intra-coronary administration of cyclosporine effectively limits infarct size, attenuates LV remodeling and preserves LV function.
關聯:	Int J Cardiol. 2011 Feb 17;147(1):79-87
显示于类别:	[護理系] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html	Intra-coronary administration of cyclosporine limits infarct size	0Kb	HTML	1831	检视/开启

在MUIR中所有的数据项都受到原著作权保护.

数据加载中.....