Meiho University Institutional Repository:Item 987654321/4222
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    题名: Exploring the Anti-Cancer Effects of Fish Bone Fermented Using Monascus purpureus: Induction of Apoptosis and Autophagy in Human Colorectal Cancer Cells
    作者: Chen, Ya-Ting
    Chen, Shu-Jen
    Hu, Chun-Yi
    Dong, Cheng-Di
    Chen, Chiu-Wen
    Singhania, Reeta Rani
    Hsieh, and Shu-Ling
    贡献者: 健康科學管理學院
    关键词: fish bone
    Monascus purpureus
    apoptosis
    autophagy
    anti-cancer
    日期: 2024-06-13
    上传时间: 2024-06-18T06:06:39Z (UTC)
    摘要: Fish bone fermented using Monascus purpureus (FBF) has total phenols and functional amino
    acids that contribute to its anti-oxidant and anti-inflammatory properties. Colorectal cancer, one of
    the most prevalent cancers and the third largest cause of death worldwide, has become a serious
    threat to global health. This study investigates the anti-cancer effects of FBF (1, 2.5 or 5 mg/mL)
    on the cell growth and molecular mechanism of HCT-116 cells. The HCT-116 cell treatment with
    2.5 or 5 mg/mL of FBF for 24 h significantly decreased cell viability (p < 0.05). The S and G2/M
    phases significantly increased by 88–105% and 25–43%, respectively (p < 0.05). Additionally, FBF
    increased the mRNA expression of caspase 8 (38–77%), protein expression of caspase 3 (34–94%),
    poly (ADP-ribose) polymerase (PARP) (31–34%) and induced apoptosis (236–773%) of HCT-116
    cells (p < 0.05). FBF also increased microtubule-associated protein 1B light chain 3 (LC3) (38–48%)
    and phosphoinositide 3 kinase class III (PI3K III) (32–53%) protein expression, thereby inducing
    autophagy (26–52%) of HCT-116 cells (p < 0.05). These results showed that FBF could inhibit HCT-116
    cell growth by inducing S and G2/M phase arrest of the cell cycle, apoptosis and autophagy. Thus,
    FBF has the potential to treat colorectal cancer.
    显示于类别:[食品營養系] 期刊論文

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