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    Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/3590


    Title: Secoiridoids from the Seed of Gonocaryum calleryanum and Their Inhibitory Potential on LPS-Induced Tumor Necrosis Factor and Nitric Oxide Production
    Authors: Cheng, Kun-Ching;Chang, Chi-I;Lin, Yu-Chi;Liu, Chih-I;Zeng, Yu-Ci;Lin, Yun-Sheng
    Keywords: Gonocaryum calleryanum;secoiridoid;structure identification;anti-inflammatory
    Date: 2018-10-03
    Issue Date: 2018-10-09
    Abstract: Abstract: Three new secoiridoid constituents, goncarin A–C (1–3), and a new derivative, goncarin A
    monoacetate (4), along with two known lignins, pinoresinol (5) and paulownin (6), were isolated
    from the seed of Gonocaryum calleryanum (Baill.) Becc. The structures of the new metabolites were
    determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and
    2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. The aim of this study was to
    identify the anti-inflammatory effects of compounds 1–6 on lipopolysaccharide (LPS)-stimulated
    murine macrophage cell lines (RAW 264.7). Following stimulation with LPS, elevated levels
    of nitric oxide (NO) production were detected in RAW 264.7 cells; however, pretreatment with
    compounds 1–6 significantly inhibited the production of NO (around 40–80%, p < 0.01–0.05),
    by suppressing the expression of inducible NO synthase (iNOS). In addition, LPS-stimulated
    tumor necrosis factor-_ (TNF-_) production was significantly reduced by compounds 1–3 (25–40%,
    p < 0.01–0.05). These results suggested that compounds 1–3 may exert anti-inflammatory activity,
    and that compounds 1–3 may be considered a potential therapeutic for the treatment of inflammatory
    diseases associated with macrophage activation.
    Appears in Collections:[Department of Biological Science and Technology] Papers

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