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http://ir.meiho.edu.tw/ir/handle/987654321/3341
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| 題名: | Increased Risk of Tics in Children Infected with Enterovirus: A Nationwide Population-Based Study |
| 作者: | Lin, Jiun-Nong;Lin, Cheng-Li;Yen, Hung-Rong;YangC, Chi-Hui;Lai, hung-Hsu;Lin, Hsi-Hsun;Kao, Chia-Hung |
| 日期: | 2017-07-11 |
| 上傳時間: | 2017-07-21T05:39:39Z (UTC)
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| 摘要: | Objective: Both tics and enterovirus (EV) infections are common in children. The association
between EV infections and tics has been seldom evaluated. The aim of this study was to evaluate the risk of
diagnosed tics after EV infections in children. Methods: A nationwide retrospective cohort study was conducted
to determine the risk of tics after EV infections by analyzing data from the National Health Insurance
Research Database in Taiwan. Children aged <18 years with EV infection during 2000 to 2007 were enrolled.
For comparison, non-EV–infected children were randomly selected and matched with EV-infected children at
a 1:1 ratio according to sex, age, urbanization level, parental occupation, and the year of EV infection. All
patients were followed up until the diagnosis of tics, death, loss to follow-up, withdrawal from the insurance
system, or December 31, 2008. Results: A total of 282,321 EV-infected and 282,317 non-EV–infected children
were included in this study. The mean age was 2.39 years in both cohorts. The overall incidences of tics were
9.12 and 6.21 per 10,000 person-years in the EV-infected and non-EV–infected cohorts, respectively. Children
with EV infection were significantly associated with an increased risk of tics compared with those without EV
infection (adjusted hazard ratio, 1.38; 95% confidence interval, 1.27–1.5). Multivariable analyses showed that
boys, children living in urbanized areas, children whose parents had white-collar jobs, and children with
allergic rhinitis or bronchial asthma exhibited a significantly increased risk of tics. Conclusion: This study
revealed an increased risk of tics after EV infection in children. |
| 顯示於類別: | [生物科技系] 期刊論文
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