Excessive workload from employment and household duties may negatively affect married female nurses’ health. Thisstudy explored job stress, family stress, social support, and health status among married female nurses to identify predictorsof nurses’ health status. Using a cross-sectional design, 233 married female nurses were recruited from two regionalteaching hospitals. The results showed that working hours per week, job stress, and overcommitment to their jobs weresignificant determinants of health status. Based on study findings, nursing supervisors should avoid scheduling nursesto work more than 48 hours per week. Job stress adjustment courses could enable nurses to relax after work, avoiding overcommitment. [Workplace Health Saf 2014;62(11):447-452.]