Meiho University Institutional Repository:Item 987654321/2623
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 2881/3806 (76%)
造访人次 : 4197566      在线人数 : 671
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于MUIR ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.meiho.edu.tw/ir/handle/987654321/2623


    题名: Methylation Status of Retinoic Acid Receptor beta2 Promoter and Global DNA in Esophageal Squamous Cell Carcinoma
    作者: RUEI-NIAN LI;FANG-JUNG YU;CHUN-CHIEH WU;YU-KUEI CHEN;CHUN-CHIEH YU
    贡献者: 健康暨護理學院
    关键词: A methylation;esophageal squamous cell carcinoma
    日期: 2014
    上传时间: 2014-11-13T02:25:47Z (UTC)
    摘要: Background: Focal hypermethylation in promoter regions of tumor suppressor genes against the background of global hypomethylation is a
    landmark of carcinogenesis. This study aimed to investigate the methylation status of retinoic acid receptor beta2 (RARb2) and long interspersed
    nuclear elements (LINE‐1) in different stages of esophageal squamous cell carcinoma (ESCC).
    Method: The tumor and adjacent normal esophageal tissues from 125 male ESCC patients who underwent primary surgery were analyzed for the
    methylation status of RARb2 promoter and LINE‐1 through methylation‐specific polymerase chain reaction and pyrosequencing.
    Results: RARb2 hypermethylation was detected in 20% of the tumor samples, but not in the normal counterparts. The methylation frequency of
    LINE‐1 was significantly lower in the tumor than in the normal parts (median: 67.7% vs. 80%, P<0.0005). Ninety‐eight patients (78.4%) had both
    RARb2 hypermethylation and LINE‐1 hypomethylation or either one. There was a trend toward higher risk of advanced T stage (P for trend¼0.05)
    or lymph node metastasis (P for trend¼0.02) when more adverse gene methylation profiles were present.
    Conclusion: Methylation status of RARb2 and LINE‐1 was related to the development and possibly the severity of ESCC.
    關聯: Journal of Surgical Oncology
    显示于类别:[食品營養系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    Methylation Status of Retinoic Acid Re.pdf272KbAdobe PDF0检视/开启


    检视Licence

    在MUIR中所有的数据项都受到原著作权保护.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈