Proteomic analysis of the differences in orbital protein expression in thyroid orbitopathy

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Title:	Proteomic analysis of the differences in orbital protein expression in thyroid orbitopathy
Authors:	Kai-Chun Cheng Han-Hsiang Huang Chun-Tzu Hung Cheng-Chi Chen Wen-Chuan Wu Jau-Ling Suen Kuo-Jen Chen Yu-Jen Wu Cheng-Hsien Chang
Contributors:	健康暨護理學院
Date:	2013
Issue Date:	2014-10-17T03:29:27Z (UTC)
Abstract:	Background Thyroid orbitopathy (TO) is a multi-system inflammatory disease characterized by orbital congestion, ocular surface disorders, restrictive myopathy, and skin lesions. The molecular and cellular processes of pathogenic formation of TO orbital fat tissues are not fully understood. In this study, a comparative proteomic analysis was conducted to investigate the importance of some differential proteins of orbital fat tissues in TO. Methods The differential proteins were analyzed by comparing the two-dimensional gel electrophoresis (2-DE) maps of the orbital fat tissues of TO with those of normal orbital fat tissues. The 2-DE results were further verified byWestern blot and immunohistochemistry.
Relation:	Graefes Arch Clin Exp Ophthalmol
Appears in Collections:	[Department of Beauty Science] Papers

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