利用蛋白質體學方法研究没食子酸對皮膚癌細胞之抗腫瘤影響

MUIR > Graduate Institute of Health Care > Department of Beauty Science > Research Projects > Item 987654321/2057

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Title:	利用蛋白質體學方法研究没食子酸對皮膚癌細胞之抗腫瘤影響
Authors:	吳裕仁;林昀生;劉至一
Contributors:	健康暨護理學院
Date:	2012
Issue Date:	2013-06-17T01:04:42Z (UTC)
Abstract:	Gallic acid (GA) has long been associated with a wide range of biological activities. In this study, its anti-tumor effect against B16F10 melanoma cells was examined by MTT assay, cell migration assay, wound healing assay and flow cytometric analysis. GA with a concentration greater than 400 M shows apoptotic activity towards B16F10 cells. According to Western blotting, over-expressions of cleaved forms of caspase-9, caspase-3, and PARP-1, and apropoptic Bax and Bad, accompanied with under-expressed antiapoptotic Bcl-2 and Bcl-XL indicates that GA induces B16F10 cell apoptosis via mitochondrial pathway.
Appears in Collections:	[Department of Beauty Science] Research Projects

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