Dietary Intake of Vitamin B6 and Risk of Breast Cancer in Taiwanese Women

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题名:	Dietary Intake of Vitamin B6 and Risk of Breast Cancer in Taiwanese Women
作者:	Chou Yu-Ching;Chu Chi-Hong;Wu Mei-Hsuan;Hsu Giu-Cheng;Yang Tsan;Chou Wan-Yun;Huang Hsin-Ping;Lee Meei-Shyuan;Yu Cheng-Ping;Yu Jyh-Cherng;Sun Chien-An
关键词:	breast cancer;ER-defined breast tumors;1-carbon metabolism;vitamin B6
日期:	2011
上传时间:	2011-09-30T08:01:07Z (UTC)
摘要:	Background: B vitamins, including vitamin B6, are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis.Methods: We examined the association of dietary vitamin B6 intake with overall breast cancer risk and breast cancers stratified by hormone receptor status. This case-control study included 391 breast cancer cases and 782 control subjects enrolled at the Tri-Service General Hospital in Taipei, Taiwan. Energy-adjusted intake of vitamin B6 was derived from a food frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.Results: As compared with women in the lowest tertile, the multivariate-adjusted ORs for breast cancer among women in the second and highest tertiles of vitamin B6 intake were 0.78 (95% CI, 0.64–2.52) and 0.64 (0.26–0.92), respectively. In addition, higher vitamin B6 intake was associated with a significantly lower risk of developing ER-negative breast tumors.Conclusions: Our findings suggest that higher intake of vitamin B6 is associated with a reduction in breast cancer risk, particularly ER-negative tumors.
關聯:	Journal of Epidemiology
显示于类别:	[健康事業管理系 ] 期刊論文

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